Selected Publications
Kirby, A.; Ward, C.; Goulet, C. S.; Calvert, N. D.; Daniel, R.; Leung, J. W.-H.; Sharma, A.; Suchý, M.; Donatelli, C.; Wang, J.; Standen, E.; Shuhendler, A. J. Aldehydic Load as an Objective Imaging Biomarker of Mild Traumatic Brain Injury. npj Imaging 2025, 3 (1), 30. DOI: 10.1038/s44303-025-00096-w.
Khorshed, A. A.; Lamontagne, H. R.; Healy, L.; Shuhendler, A. J.; Lessard, B. H. Monitoring Ketoacidosis and Ketosis through Electrochemical Sensing of Acetone and Acetoacetate in Biological Fluids after Dilution. Sens. Actuators, B2025, 433, 137557. https://doi.org/10.1016/j.snb.2025.137557
Kitos, A. A.; Castañeda, R.; Comeau, Z. J.; Mavragani, N.; Calvert, N. D.; Kirby, A.; Martínez-Santiesteban, F. M.; Pallister, P. J.; Scholl, T. J.; Murugesu, M.; Shuhendler, A. J.; Brusso, J. L. Cluster-Based Redox-Responsive Super-Atomic MRI Contrast Agents. Chem 2025, 11 (3), 102330. DOI: 10.1016/j.chempr.2024.09.029
Calvert, N. D.; Baxter, J.; Torrens, A. A.; Thompson, J.; Kirby, A.; Walia, J.; Ntais, S.; Hemmer, E.; Berini, P.; Hibbert, B.; Ramunno, L.; Shuhendler, A. J. NIR-II Scattering Gold Superclusters for Intravascular Optical Coherence Tomography Molecular Imaging. Nat. Nanotechnol. 2025, 20 (2), 276–285. DOI: 10.1038/s41565-024-01802-2.
Calvert, N. D.; Yu, L.; Sehl, O. C.; Gevaert, J. J.; Knier, N. N.; Rivera-Rodriguez, A.; Goulet, C. S.; Fernando, N.; Flood, S.; Rinaldi-Ramos, C. M.; Foster, P. J.; Shuhendler, A. J. The Careful Selection of Zwitterionic Nanoparticle Coating Results in Rapid and Efficient Cell Labeling for Imaging-Based Cell Tracking. Aggregate 2024, 5 (6), Article e609. DOI: 10.1002/agt2.609
Kirby, A.; Suchý, M.; Shuhendler, A. J. MRI Probes for In Vivo Aldehyde Sensing. Analysis and Sensing 2024, 4, 10.1002/anse.202300087
Kirby, A.; Graf, D.; Suchý, M.; Calvert, N. D.; Charlton, T. A.; Ben, R. N.; Addison, C. L.; Shuhendler, A. J. It’s a Trap! Aldolase-Prescribed C4 Deoxyradiofluorination Affords Intracellular Trapping and the Tracing of Fructose Metabolism by PET. J. Nucl. Med. 2024, 65 (3), jnumed.123.266905. DOI: 10.2967/jnumed.123.266905.
Tracking the fate of bacteria-derived site-specific immunomodulators by positron emission tomography
Kirby, A.; Suchý, M.; Duan, D.; Bazett, M.; Kalyan, S.; Shuhendler, A. J. Tracking the Fate of Bacteria-Derived Site-Specific Immunomodulators by Positron Emission Tomography. Nucl. Med. Biol. 2024, 132-133, 108908. DOI: 10.1016/j.nucmedbio.2024.108908
Karlin, L.; Lamontagne, H. R.; Chaurasia, S.; Triglav, M.; Harris, C. S.; Shuhendler, A. J.; Brusso, J. L.; Lessard, B. H. Soluble Zinc Phthalocyanines as Chemical Probes for Δ-9-Tetrahydrocannabinol in Different Solvents. J. Porphyrins Phthalocyanines 2024, 28 (6), 349-357. DOI: 10.1142/S1088424624500081
Lamontagne, H. R., Comeau, Z. J., Cranston, R. R., Boileau, N. T., Harris, C. S., Shuhendler, A. J., and Lessard, B. H. Sens. Diagn., 2022,1, 1165-1175. doi: 10.1039/D2SD00071G.
Calvert ND, Kirby A, Suchý M, Pallister P, Torrens AA, Burger D, Melkus G, Schieda N, Shuhendler AJ. Nat Commun. 2023 Jul 5;14(1):3965. doi: 10.1038/s41467-023-39720-x.
Comeau, Z. J., Cranston, R. R., Lamontagne, H. R., Shuhendler, A. J., Lessard, B. H. Small 2023, 19, 2206792. https://doi.org/10.1002/smll.202206792
Comeau ZJ, Rice NA, Harris CS, Shuhendler AJ, Lessard BH. Adv Func Mat. 2021 2107138. doi: 10.1002/adfm.202107138
Brun EMSP-T, Calvert ND, Suchy M, Kirby A, Melkus G, Garipov R, Addison CL, Shuhendler AJ.
Chem Commun. 2021 Oct 19;57(83):10867-10870. doi: 10.1039/d1cc03704h
Comeau ZJ, Cranston RR, Lamontagne HR, Harris CS, Shuhendler AJ, Lessard BH. Commun Chem. 2022 Dec 24;5(1):178. doi: 10.1038/s42004-022-00797-y.
Suchy M, Kirby A, Sabloff T, Mulvihill EE, Shuhendler AJ.
New J. Chem. 2021 Jul 1; 45(29): 13185-13195. doi: 10.1039/D1NJ02393D
Suchy M, Charlton TA, Ben RN, Shuhendler AJ.
Carb. Res. 2021 Sep;507:108377. doi: 10.1016/j.carres.2021.108377.
Comeau ZJ, Facey GA, Harris CS, Shuhendler AJ, Lessard BH.
ACS Appl Mater Interfaces. 2020 Nov 11; 12(45): 50692- 50702. doi: 10.1021/acsami.0c17146
Comeau ZJ, Boileau NT, Lee T, Melville OA, Rice NA, Troung Y, Harris CS, Lessard BH, Shuhendler AJ.
ACS Sens. 2019 Oct 25;4(10):2706-2715. doi: 10.1021/acssensors.9b01150.
Yan R, Hu Y, Liu F, Wei S, Fang D, Shuhendler AJ, Liu H, Chen HY, Ye D
J Am Chem Soc. 2019 Jul 3;141(26):10331-10341. doi: 10.1021/jacs.9b03649
Kirby A*,Suchý M*, Brouwer A, Shuhendler A.
Chem Commun (Camb). 2019 May 10;55(37):5371-5374. doi: 10.1039/c9cc01831j
*Authors contributed equally
Shuhendler A, Cui L, Chen Z, Shen B, Chen M, James ML, Witney TH, Gambhir SS, Chin FT, Bazalova-Carter M, Graves EE, Rao J
Bioconjug Chem. 2019 May 15;30(5):1331-1342. doi: 10.1021/acs.bioconjchem.9b00089
Liu N, Marin R, Mazouzi Y, Cron GO, Shuhendler A, Hemmer E.Nanoscale. 2019 Mar 18;11: 6794-6801. doi: 10.1039/c9cc01831J.
Suchý M, Lazurko C, Kirby A, Dang T, Liu G, Shuhendler A.Organic & Biomolecular Chemistry. 2019 Feb 13;17(7):1843-1853. doi: 10.1039/c8ob02255k.
Lazurko C, Radonjic I, Suchý M, Liu G, Rolland-Lagan AG, Shuhendler A. Chembiochem. 2019 Feb 15;20(4):543-554. doi: 10.1002/cbic.201800427.
Dang T, Suchy M, Truong YJ, Oakden W, Lam WW, Lazurko C, Facey G, Stanisz GJ, Shuhendler AJ.
Chemistry: A European Journal. 2018 Jun 26;24(36):9148-9156. doi: 10.1002/chem.201801671.
Shen Y, Shuhendler AJ, Ye D, Xu JJ, Chen HY.
Chem Soc Rev. 2016 Dec 21;45(24):6725-6741.
Shuhendler AJ, Ye D, Brewer KD, Bazalova-Carter M, Lee KH, Kempen P, Dane Wittrup K, Graves EE, Rutt B, Rao J.
Sci Rep. 2015 Oct 6;5:14759. doi: 10.1038/srep14759.
Ye D, Shuhendler AJ, Cui L, Tong L, Tee SS, Tikhomirov G, Felsher DW, Rao J.
Nat Chem. 2014 Jun;6:519-26. doi: 10.1038/nchem.1920.
Shuhendler AJ, Pu K, Cui L, Uetrecht JP, Rao J.
Nat Biotechnol. 2014 Apr;32(4):373-80. doi: 10.1038/nbt.2838.
Pu K, Shuhendler AJ, Jokerst JV, Mei J, Gambhir SS, Bao Z, Rao J.
Nat Nanotechnol. 2014 Mar;9(3):233-9. doi: 10.1038/nnano.2013.302.
Patents
Compositions with metal nanoparticles, their methods of manufacture and their uses
Shuhendler, A. J.; Calvert, N. D. Biomarkers and Methods for Detecting Mild Traumatic Brain Injury. U.S. Patent Application US20250099627A1, Published March 27, 2025; Yellowbird Diagnostics Inc.
Verdazyl compounds as contrast agents for magnetic resonance imaging of kidneys
Calvert, N. D.; Kirby, A. M.; Torrens, A. A.; Shuhendler, A. J. Biomarkers and Methods for Detecting Mild Traumatic Brain Injury. WO2024192530A1, Published September 26, 2024; Yellowbird Diagnostics Inc.
METHODS AND COMPOUNDS FOR DETECTION AND BINDING OF ALDEHYDES
Shuhendler, A.; Suchý, M.; Dang, T.; Kirby, A.; Graf, D. Methods and Compositions for Imaging Aldehydic Load. U.S. Patent Application US20230358732A1, Published November 9, 2023; University of Ottawa
PROBE FOR IMAGING PARP-1 ACTIVITY
SHUHENDLER, Adam; CUI Lina; RAO, Jianghong
Stanford University
U.S. Patent 10196412
Devices and methods for selective detection of cannabinoids
SHUHENDLER Adam, LESSARD Benoît, HARRIS Cory, BOILEAU Nicholas, COMEAU Zachary
University of Ottawa
U.S. Patent Application 62/849,340 (2019)
Caspase-triggered nano-aggregation probes and methods of use
RAO, Jianghonh; YE, Deju; SHUHENDLER, Adam; CHIN, Frederick; JEON Jongho; SHEN, Bin
Stanford University
U.S. Patent 9642922
METHODS AND COMPOUNDS FOR DETECTION AND BINDING OF ALDEHYDES
SHUHENDLER, Adam; SUCHY, Mojmir; DANG, Trina
University of Ottawa
PCT CA2018/050125 (February 5, 2018)
Nanoprobes for sensing of reactive oxygen and reactive nitrogen species
SHUHENDLER, Adam; PU, Kanyi; RAO, Jianghong
Stanford University
U.S. Patent 9675713
Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes
SHUHENDLER, Adam; PU, Kanyi; RAO, Jianghong
Stanford University
US Prov. Patent 2015/0031996A1 (July 24, 2013)
Discrete imaging of hepatic oxidative and nitrosative stress with two-channel nanoparticles for in vivo drug safety screening
SHUHENDLER, Adam; PU, Kanyi; RAO, Jianghong
Stanford University
U.S. Patent 9849198
Fatty ester-based particles and methods of preparation and use thereof
SHUHENDLER, Adam; WU, XiaoYu
University of Toronto
WO 2012/109755A1 (February 16, 2011)