Selected Publications
Kirby, A.; Ward, C.; Goulet, C. S.; Calvert, N. D.; Daniel, R.; Leung, J. W.-H.; Sharma, A.; Suchý, M.; Donatelli, C.; Wang, J.; Standen, E.; Shuhendler, A. J. Aldehydic Load as an Objective Imaging Biomarker of Mild Traumatic Brain Injury. npj Imaging 2025, 3 (1), 30. DOI: 10.1038/s44303-025-00096-w.
Khorshed, A. A.; Lamontagne, H. R.; Healy, L.; Shuhendler, A. J.; Lessard, B. H. Monitoring Ketoacidosis and Ketosis through Electrochemical Sensing of Acetone and Acetoacetate in Biological Fluids after Dilution. Sens. Actuators, B2025, 433, 137557. https://doi.org/10.1016/j.snb.2025.137557
Kitos, A. A.; Castañeda, R.; Comeau, Z. J.; Mavragani, N.; Calvert, N. D.; Kirby, A.; Martínez-Santiesteban, F. M.; Pallister, P. J.; Scholl, T. J.; Murugesu, M.; Shuhendler, A. J.; Brusso, J. L. Cluster-Based Redox-Responsive Super-Atomic MRI Contrast Agents. Chem 2025, 11 (3), 102330. DOI: 10.1016/j.chempr.2024.09.029
Calvert, N. D.; Baxter, J.; Torrens, A. A.; Thompson, J.; Kirby, A.; Walia, J.; Ntais, S.; Hemmer, E.; Berini, P.; Hibbert, B.; Ramunno, L.; Shuhendler, A. J. NIR-II Scattering Gold Superclusters for Intravascular Optical Coherence Tomography Molecular Imaging. Nat. Nanotechnol. 2025, 20 (2), 276–285. DOI: 10.1038/s41565-024-01802-2.
Calvert, N. D.; Yu, L.; Sehl, O. C.; Gevaert, J. J.; Knier, N. N.; Rivera-Rodriguez, A.; Goulet, C. S.; Fernando, N.; Flood, S.; Rinaldi-Ramos, C. M.; Foster, P. J.; Shuhendler, A. J. The Careful Selection of Zwitterionic Nanoparticle Coating Results in Rapid and Efficient Cell Labeling for Imaging-Based Cell Tracking. Aggregate 2024, 5 (6), Article e609. DOI: 10.1002/agt2.609
Kirby, A.; Suchý, M.; Shuhendler, A. J. MRI Probes for In Vivo Aldehyde Sensing. Analysis and Sensing 2024, 4, 10.1002/anse.202300087
Kirby, A.; Graf, D.; Suchý, M.; Calvert, N. D.; Charlton, T. A.; Ben, R. N.; Addison, C. L.; Shuhendler, A. J. It’s a Trap! Aldolase-Prescribed C4 Deoxyradiofluorination Affords Intracellular Trapping and the Tracing of Fructose Metabolism by PET. J. Nucl. Med. 2024, 65 (3), jnumed.123.266905. DOI: 10.2967/jnumed.123.266905.
Tracking the fate of bacteria-derived site-specific immunomodulators by positron emission tomography
Kirby, A.; Suchý, M.; Duan, D.; Bazett, M.; Kalyan, S.; Shuhendler, A. J. Tracking the Fate of Bacteria-Derived Site-Specific Immunomodulators by Positron Emission Tomography. Nucl. Med. Biol. 2024, 132-133, 108908. DOI: 10.1016/j.nucmedbio.2024.108908
Karlin, L.; Lamontagne, H. R.; Chaurasia, S.; Triglav, M.; Harris, C. S.; Shuhendler, A. J.; Brusso, J. L.; Lessard, B. H. Soluble Zinc Phthalocyanines as Chemical Probes for Δ-9-Tetrahydrocannabinol in Different Solvents. J. Porphyrins Phthalocyanines 2024, 28 (6), 349-357. DOI: 10.1142/S1088424624500081
Lamontagne, H. R., Comeau, Z. J., Cranston, R. R., Boileau, N. T., Harris, C. S., Shuhendler, A. J., and Lessard, B. H. Sens. Diagn., 2022,1, 1165-1175. doi: 10.1039/D2SD00071G.
Calvert ND, Kirby A, Suchý M, Pallister P, Torrens AA, Burger D, Melkus G, Schieda N, Shuhendler AJ. Nat Commun. 2023 Jul 5;14(1):3965. doi: 10.1038/s41467-023-39720-x.
Comeau, Z. J., Cranston, R. R., Lamontagne, H. R., Shuhendler, A. J., Lessard, B. H. Small 2023, 19, 2206792. https://doi.org/10.1002/smll.202206792
Comeau ZJ, Rice NA, Harris CS, Shuhendler AJ, Lessard BH. Adv Func Mat. 2021 2107138. doi: 10.1002/adfm.202107138
Brun EMSP-T, Calvert ND, Suchy M, Kirby A, Melkus G, Garipov R, Addison CL, Shuhendler AJ.
Chem Commun. 2021 Oct 19;57(83):10867-10870. doi: 10.1039/d1cc03704h
Comeau ZJ, Cranston RR, Lamontagne HR, Harris CS, Shuhendler AJ, Lessard BH. Commun Chem. 2022 Dec 24;5(1):178. doi: 10.1038/s42004-022-00797-y.
Suchy M, Kirby A, Sabloff T, Mulvihill EE, Shuhendler AJ.
New J. Chem. 2021 Jul 1; 45(29): 13185-13195. doi: 10.1039/D1NJ02393D
Suchy M, Charlton TA, Ben RN, Shuhendler AJ.
Carb. Res. 2021 Sep;507:108377. doi: 10.1016/j.carres.2021.108377.
Comeau ZJ, Facey GA, Harris CS, Shuhendler AJ, Lessard BH.
ACS Appl Mater Interfaces. 2020 Nov 11; 12(45): 50692- 50702. doi: 10.1021/acsami.0c17146
Comeau ZJ, Boileau NT, Lee T, Melville OA, Rice NA, Troung Y, Harris CS, Lessard BH, Shuhendler AJ.
ACS Sens. 2019 Oct 25;4(10):2706-2715. doi: 10.1021/acssensors.9b01150.
Yan R, Hu Y, Liu F, Wei S, Fang D, Shuhendler AJ, Liu H, Chen HY, Ye D
J Am Chem Soc. 2019 Jul 3;141(26):10331-10341. doi: 10.1021/jacs.9b03649
Kirby A*,Suchý M*, Brouwer A, Shuhendler A.
Chem Commun (Camb). 2019 May 10;55(37):5371-5374. doi: 10.1039/c9cc01831j
*Authors contributed equally
Shuhendler A, Cui L, Chen Z, Shen B, Chen M, James ML, Witney TH, Gambhir SS, Chin FT, Bazalova-Carter M, Graves EE, Rao J
Bioconjug Chem. 2019 May 15;30(5):1331-1342. doi: 10.1021/acs.bioconjchem.9b00089
Liu N, Marin R, Mazouzi Y, Cron GO, Shuhendler A, Hemmer E.Nanoscale. 2019 Mar 18;11: 6794-6801. doi: 10.1039/c9cc01831J.
Suchý M, Lazurko C, Kirby A, Dang T, Liu G, Shuhendler A.Organic & Biomolecular Chemistry. 2019 Feb 13;17(7):1843-1853. doi: 10.1039/c8ob02255k.
Lazurko C, Radonjic I, Suchý M, Liu G, Rolland-Lagan AG, Shuhendler A. Chembiochem. 2019 Feb 15;20(4):543-554. doi: 10.1002/cbic.201800427.
Dang T, Suchy M, Truong YJ, Oakden W, Lam WW, Lazurko C, Facey G, Stanisz GJ, Shuhendler AJ.
Chemistry: A European Journal. 2018 Jun 26;24(36):9148-9156. doi: 10.1002/chem.201801671.
Shen Y, Shuhendler AJ, Ye D, Xu JJ, Chen HY.
Chem Soc Rev. 2016 Dec 21;45(24):6725-6741.
Shuhendler AJ, Ye D, Brewer KD, Bazalova-Carter M, Lee KH, Kempen P, Dane Wittrup K, Graves EE, Rutt B, Rao J.
Sci Rep. 2015 Oct 6;5:14759. doi: 10.1038/srep14759.
Ye D, Shuhendler AJ, Cui L, Tong L, Tee SS, Tikhomirov G, Felsher DW, Rao J.
Nat Chem. 2014 Jun;6:519-26. doi: 10.1038/nchem.1920.
Shuhendler AJ, Pu K, Cui L, Uetrecht JP, Rao J.
Nat Biotechnol. 2014 Apr;32(4):373-80. doi: 10.1038/nbt.2838.
Pu K, Shuhendler AJ, Jokerst JV, Mei J, Gambhir SS, Bao Z, Rao J.
Nat Nanotechnol. 2014 Mar;9(3):233-9. doi: 10.1038/nnano.2013.302.
Patents
Devices and methods for selective detection of cannabinoids
SHUHENDLER Adam, LESSARD Benoît, HARRIS Cory, BOILEAU Nicholas, COMEAU Zachary
University of Ottawa
U.S. Patent Application 62/849,340 (2019)
PROBE FOR IMAGING PARP-1 ACTIVITY
SHUHENDLER, Adam; CUI Lina; RAO, Jianghong
Stanford University
U.S. Patent 10196412
Caspase-triggered nano-aggregation probes and methods of use
RAO, Jianghonh; YE, Deju; SHUHENDLER, Adam; CHIN, Frederick; JEON Jongho; SHEN, Bin
Stanford University
U.S. Patent 9642922
METHODS AND COMPOUNDS FOR DETECTION AND BINDING OF ALDEHYDES
SHUHENDLER, Adam; SUCHY, Mojmir; DANG, Trina
University of Ottawa
PCT CA2018/050125 (February 5, 2018)
Nanoprobes for sensing of reactive oxygen and reactive nitrogen species
SHUHENDLER, Adam; PU, Kanyi; RAO, Jianghong
Stanford University
U.S. Patent 9675713
METHODS AND COMPOUNDS FOR DETECTION AND BINDING OF ALDEHYDES
Shuhendler, A.; Suchý, M.; Dang, T.; Kirby, A.; Graf, D. Methods and Compositions for Imaging Aldehydic Load. U.S. Patent Application US20230358732A1, Published November 9, 2023; University of Ottawa
Verdazyl compounds as contrast agents for magnetic resonance imaging of kidneys
Calvert, N. D.; Kirby, A. M.; Torrens, A. A.; Shuhendler, A. J. Biomarkers and Methods for Detecting Mild Traumatic Brain Injury. WO2024192530A1, Published September 26, 2024; Yellowbird Diagnostics Inc.
Compositions with metal nanoparticles, their methods of manufacture and their uses
Shuhendler, A. J.; Calvert, N. D. Biomarkers and Methods for Detecting Mild Traumatic Brain Injury. U.S. Patent Application US20250099627A1, Published March 27, 2025; Yellowbird Diagnostics Inc.
Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes
SHUHENDLER, Adam; PU, Kanyi; RAO, Jianghong
Stanford University
US Prov. Patent 2015/0031996A1 (July 24, 2013)
Discrete imaging of hepatic oxidative and nitrosative stress with two-channel nanoparticles for in vivo drug safety screening
SHUHENDLER, Adam; PU, Kanyi; RAO, Jianghong
Stanford University
U.S. Patent 9849198
Fatty ester-based particles and methods of preparation and use thereof
SHUHENDLER, Adam; WU, XiaoYu
University of Toronto
WO 2012/109755A1 (February 16, 2011)